How do Shp2 mutations that oppositely influence its biochemical activity result in syndromes with overlapping symptoms?

Activating and inactivating mutations of SHP-2 are responsible, respectively, for the Noonan (NS) and the LEOPARD (LS) syndromes. Clinically, these developmental disorders overlap greatly, resulting in the apparent paradox of similar diseases caused by mutations that oppositely influence SHP-2 phosphatase activity. While the mechanisms remain unclear, recent functional analysis of SHP-2, along with the identification of other genes involved in NS and in other related syndromes (neurofibromatosis-1, Costello and cardio-facio-cutaneous syndromes), strongly suggest that Ras/MAPK represents the major signaling pathway deregulated by SHP-2 mutants. We discuss the idea that, with the exception of LS mutations that have been shown to exert a dominant negative effect, all disease-causing mutations involved in Ras/MAPK-mediated signaling, including SHP-2, might lead to enhanced MAPK activation. This suggests that a narrow range of MAPK signaling is required for appropriate development. We also discuss the possibility that LS mutations may not simply exhibit dominant negative activity. Received 30 November 2006; received after revision 8 February 2007; accepted 13 March 2007     

纳米固体超强酸SO42-/ZnO催化合成乙酸异戊酯的研究

本文利用纳米固体超强酸SO4^2-/ZnO催化合成乙酸异戊酯的最佳反应条件,既反应时间2.0h,催化剂用量为酸质量的1.0%,酸醇比为1∶2,验证实验产率为96.7%,且该实验反应时间短,无腐蚀无污染,催化剂可回收可重复利用.     

考虑经纪人投资情绪的委托代理合同研究

从行为金融学角度,提出将经纪人的投资情绪考虑进资本市场的委托代理关系中.通过建立数学模型,分析了非理性经纪人的投资决策给委托人带来的影响,得到了此时委托人与经纪人之间的最优委托代理合同.结果表明,经纪人的乐(悲)观投资情绪可以使委托人的代理成本得到补偿,并且委托人对经纪人的最优激励强度随着经纪人乐(悲)观程度的增加而降低.这说明在一定条件下,经纪人的乐(悲)观投资情绪,对委托人具有积极意义.     

Picturing the moon: Hevelius’s and Riccioli’s visual debate

This article investigates the maps of the moon produced in the mid-seventeenth century by Jesuit Giambattista Riccioli (1598-1671) and Johannes Hevelius (1611-1687), whose cartographic projects competed for widespread acceptance. Although Hevelius’s Selenographia (1647) was applauded for its many detailed, self-engraved pictures of the moon, his cartography and proposed nomenclature were supplanted by Riccioli’s as offered in Almagestum novum (1651), in spite of the latter’s simplistic pictures and promotion of geocentric cosmology. Exploring this paradox through pictorial analysis, three types of images common to both Selenographia and Almagestum novum are compared, employing an analytical tool developed by Svetlana Alpers in The art of describing (1983). A focus on this debate exposes the tensions evoked by new technologies of vision and competing cultures of visual epistemology in seventeenth-century astronomy. As both selenographers grappled with questions about the role of representation and what kinds of knowledge could be generated visually, the successes and failures of their competing projects present implications for the course of visual astronomy, as well as for our understanding of the use of ‘visual technologies’ in a period of controversy.     

Common Molecular Mechanisms of Mammary Gland Development and Breast Cancer

During its lifetime, the mammary gland undergoes many phases of development and differentiation. Much of this occurs during puberty, when the ductal epithelium expands by branching morphogenesis, invading the surrounding fat pad to form an organised mammary tree. Throughout its existence, the epithelium will go through several cycles of proliferation and cell death during pregnancy, lactation and involution. Many of the signalling mechanisms which control the initial invasion of the fat pad by the epithelium, and regulate its continuing plasticity, can be harnessed or corrupted by tumour cells in order to support their aberrant growth and progression towards invasion. This is true not just for the epithelial cells themselves but also for cells in the surrounding microenvironment, including fibroblasts, macrophages and adipocytes. This review examines the complex web of signalling and adhesion interactions controlling branching morphogenesis, and how their alteration can promote malignancy. Current in vivo and in vitro mammary gland models are also discussed. (Part of a Multi-author Review)     

1997～2002年《河南大学学报》（自然版）载文及引文分析

运用文献计量学的研究方法，对1997～2002年《河南大学学报》(自然版)所载论文的数量、学科、基金项目及引文进行了统计分析，以期帮助编辑和读者通过数据客观认识《学报》的学术价值和编辑特点。     

核磁共振成像用磁体的计算机辅助设计

核磁共振成像用的磁体要求在一定的磁场强度下保持大范围的均匀度。本文给出球形空芯磁体和环形空芯磁体的计算机辅助设计方法。     

关于2-群的注记

通过对2-群的研究，得到了一类2-群的结构，进而给出了一类无限2-群有无限的阿贝尔子群的例子．     

LF拓扑空间中T21/2分离公理的几个性质

给出LF拓扑空间中T212分离公理的三条重要性质,即弱同胚不变性、相对可积性和可和性.     

DEA-based anti-HIV immunotherapy model

Acquiredimmunitydeficiencysyndrome(AIDS)isoneofthemostfataldiseasesthathasspreadacrossthewholeworldsinceitfirstoccurred.Itiscausedbythehumanimmunodeficiencyvirus(HIV)[1].Mostofthechemotherapiesareaimedatkillingorhaltingthepathogen,butanewtreatmentistoreduceviralpopulationandimprovetheimmuneresponse.Thistreatmentcanboosttheimmunesystemandservetohelpthebodyfightinfectiononitsown,soitiscalledantiHIVimmunotherapy[2,3].TheaimofthisworkistofindefficientstrategiesforsuchtreatmentsusingtheDataEnv…